Boston is the capital and most populous city of the Commonwealth of Massachusetts and the largest city in New England. Its estimated city-proper population was 596,638 in 2005. The city lies at the center of America's eleventh-largest metropolitan area known as Greater Boston, which is home to 4.4 million people. Residents of the city are called Bostonians. Boston was founded in 1630. During the late 1700s, it was the location of several major events, including the Boston Massacre and the Boston Tea Party. During the American Revolution, the Battle of Bunker Hill and the Siege of Boston occurred within the city and surrounding areas. Boston became a major shipping port and manufacturing center. It was the site of America's first public school, Boston Latin School (1635), first college, Harvard (1636) , and the first subway system in the U.S. Boston has become one of the most culturally significant cities in the United States. With many colleges and universities within the city and surrounding area, Boston is a center of higher education and a center for health care. The city's economy is also based on research, finance, technology and biotech.